A sustainable C–H functionalization of indoles, pyrroles and furans
Professor Ludovic Gremaud, PhD from ChemTech Institute and the team of the department of Chemistry from the Shiv Nadar University in India, led by Prof. Subhabrata Sen. PhD, FRSC, discovered a sustainable C–H functionalization of indoles, pyrroles and furan and published their breakthrough in the Organic & Biomolecular Chemistry journal.
Pyrrole and indole derivatives are functionalized via a green initiative with the dimethyl malonate derived phenyl iodonium ylide in the presence of a blue LED via C–H functionalization of the respective heterocycles in methanol to generate the desired compounds in moderate to good yields. Control experiments provide insight into the probable reaction mechanism. Finally, the strategy is successfully applied in the generation of azepino[4,5-b]indole.
ChemTech congratulates them warmly for this achievement !
To read the article, you can click here.